Activity Test of Lime Peel Extract Nanoemulsion Preparation (Citrus Aurantifolia) on Reducing SGOT-SGPT Levels, Assessment of Necrosis, Fibrosis and Liver Lobules in Wistar Rats(Rattus Norvegicus) Streptozotocin-Induced

Abstract

In humans, the liver is an organ involved in various processes important for life.Insulin resistance can lead to chronic liver damage, such as cirrhosis and liver failure. SGOT and SGPT are two enzymes produced by liver cells and used to assess liver function. Elevated SGOT and SGPT levels can be caused by hepatitis, fatty liver disease, gallbladder obstruction, and other diseases. This study was conducted toto see how the activity of lime peel extract nanoemulsion preparation (Citrus aurantifolia) reduces SGOT-SGPT levels, assesses the level of necrosis, fibrosis and liver lobules in rat strains(Rattus Norvegicus)streptozotocin-induced. A sample of 25 mice in 4 groups (control, treatment 1, 2, and 3) where the extract preparation in the treatment was in the form ofnanoemulsion of lime peel extract (Citrus aurantifolia) at concentrations F1 (1%), F2 (1.5%) and F3 (2%). The results observed inDiabetes mellitus can cause liver dysfunction. AndLime peel (Citrus aurantifolia) extract nanoemulsion is effective for treating liver function in diabetic rats and the effective extract concentration sequence is F3 (2%), F2 (1.5%) and F1 (1%).