Activity Test of Cinnamon Bark Extract ( Cinnamomum Burmannii ) Nanoemulsion Preparation on Reducing Urea, Creatinine, and Kidney Histopathology in Male Rats Induced by Alloxan

Abstract

This study aims to test the activity of a nanoemulsion preparation of cinnamon bark extract ( Cinnamomum burmannii ) in reducing urea and creatinine levels, and evaluating the histopathological features of the kidneys in alloxan-induced male rats. Rats were divided into several groups, including a control group and a group treated with a nanoemulsion preparation of cinnamon bark extract. Urea and creatinine levels were measured to assess kidney function, while histopathological analysis was performed to evaluate changes in kidney tissue morphology. The results showed that treatment with a nanoemulsion preparation of cinnamon bark extract significantly reduced urea and creatinine levels and improved the histopathological features of the kidneys compared to the control group. Nanoemulsion of cinnamon bark extract (Cinnamomum burmannii) was proven to be effective in reducing blood glucose, urea, and creatinine levels in male white rats (Rattus norvegicus) of the Wistar strain induced by alloxan. The treatment group given nanoemulsion with a concentration of 20% showed the most optimal results, with a significant decrease in blood sugar, urea, and creatinine levels, approaching the values shown by the negative control group. In histopathological examination of the kidneys, the 20% treatment group also showed minimal tissue damage, characterized by only mild thickening of the glomerular basement membrane, compared to the other groups. These findings suggest the potential of cinnamon bark extract as a nephroprotective agent in the management of diabetes-induced kidney damage.