GC-MS Identification of Lime Peel Extract Nanoemulsion (Citrus Aurantifolia) Against the LevelsGDP,HbA1c and MDA And Histopathological Image of Pancreas of Male Wistar Rats Induced by Streptozotocin

Abstract

Some people may not realize they have diabetes because they do not experience any symptoms..In some cases, the disease can be detected early with routine blood tests before symptoms appear.This study aims to identify the GC-MS of lime peel extract nanoemulsion (Citrus aurantifolia) against the levels ofGDP,HbA1c and MDAand histopathological picture of the pancreas of rats. Male Wistar rats induced by streptozotocin. A sample of 24 rats in 4 groups (control, treatment 1, 2, and 3) where the extract preparation in the treatment was in the form ofNanoemulsion of lime peel extract (Citrus aurantifolia) at concentrations F1 (1%), F2 (1.5%) and F3 (2%). The results showed that the compounds contained in lime extract (Citrus aurantifolia) through GC-MS analysis werelimonene, hesperidin, and limonin. Fasting blood sugar levels (GDP), glycated hemoglobin levels(HbA1c) and levelsMalondialdehyde (MDA) levels improved in the group given lime extract nanoemulsion.(Citrus aurantifolia), and the most effective is given at a concentration of 2%. In the observation of the pancreas organs of mice through histopathology of the pancreas of mice, it was seen that the administration of lime extract nanoemulsioneffective in healing pancreatic cells that suffer from diabetes mellitus.