Effectiveness Test of Mangosteen Peel Extract (Garcinia Mangostana L) Nanoemulsion Preparation on the LevelsGDP,HbA1c, MDAAnd Histopathological Image of the Pancreas of Alloxan-Induced Diabetes Mellitus Rats

Abstract

A bad lifestyle can cause diabetes.Mostly, diabetes mellitus is caused by uncontrolled food consumption or side effects from the use of certain drugs.This research was conducted to see howThe effectiveness of nanoemulsion preparation of mangosteen peel extract (Garcinia mangostana L.) on GDP, HbA1c and MDA levels and histopathological features of the pancreas of alloxan-induced diabetic rats. The study usedA sample of 20 mice in 5 groups (positive control, negative, treatment 1, 2 and 3) where the extract preparation in the treatment was in the form ofnanoemulsion of skin extractmangosteen peel extract (Garcinia Mangostana L)onconcentration of F1 (1%), F2 (2%), and F3 (3%). The results of the GDP levels of groups P1, P2 and P3 are105.5 mg/dL, 92 mg/dL, 86.5 mg/dL. For blood sugar levelsHbA1c levels were 5.3%, 4.8%, and 4.6%, respectively, and MDA levels were 3.22%.nmol/mL, 2.6 nmol/mL and 2.25 nmol/mL. Administration of mangosteen peel extract nanoemulsion (Garcinia Mangostana L)effective in healing pancreatic cells that suffer from diabetes mellitus andadministration at a concentration of 3% extract showed that pancreatic cells no longer experienced necrosis.