The Effectiveness of Star Anise (Illicium Verum) Extract Nanoemulsion on Malondialdehyde (MDA) and Blood Glucose Levels (BGL) and Histopathological Features of Alloxan-Induced Rat Liver

Abstract

Diabetes mellitus is a collective term for heterogeneous metabolic disorders whose main finding is chronic hyperglycemia. High MDA levels in the liver are associated with liver damage and non-alcoholic fatty liver disease (NAFLD). This study aims to test and analyze the effectiveness of star anise (Illicium verum) extract nanoemulsion preparations on reducing MDA levels, KGD, and liver histopathology in alloxan-induced male Wistar rats (Rattus norvegicus). The sample of rats used was 24 in 4 groups (control, treatment 1, 2 and 3) where the extract preparation in the treatment was star anise (Illicium verum) extract nanoemulsion with concentrations of 10% and 20%. Administration of star anise extract nanoemulsion, especially at a concentration of 20%, showed a significant decrease in blood glucose levels approaching the value of the negative control group (p = 0.333)