Activity Test of Ginger (Zingiber Officinale) Extract Nanoemulsion on Decreasing Sgpt, Sgot Levels, Assessment of Necrosis, Fibrosis and Liver Lobules in Male Rats Induced by Streptozotocin and Histopathological of the Liver

Abstract

This study aims to test the activity of ginger ( Zingiber officinale ) extract nanoemulsion on reducing SGPT and SGOT levels, as well as assessing the level of necrosis, fibrosis, and liver lobule condition in streptozotocin-induced male rats. Rats were divided into control and treatment groups, where the treatment group received ginger extract nanoemulsion preparation. The results showed that treatment with nanoemulsion significantly reduced SGPT and SGOT levels, as well as reduced the level of necrosis and fibrosis in liver tissue compared to the control group. Phytochemical screening results on ginger ( Zingiber officinale ) extract revealed the presence of flavonoids, tannins, saponins, alkaloids, and polyphenols. These compounds act as natural antioxidants that support antidiabetic effects in test animals. Treatment group 3 with a nanoemulsion of ginger extract ( zingiber officinale ) at a dose of 200 mg/kgBW experienced a significant decrease in SGOT and SGPT levels compared to the other treatment groups, approaching the control group. The ANOVA test showed a significant difference between groups (p < 0.05), which was confirmed by the results of the LSD test. Microscopic image of the liver of mice in treatment group 3 showed improvement. structure histology heart However Still There is degeneration hydropic , so that Still enter in category Score 1. The percentage of necrosis decreased to 5% . Histopathological findings showed improvements in the structure of the liver lobules. This study concluded that ginger extract nanoemulsion preparations can function as an effective therapy in protecting the liver from diabetes-induced damage.