The Effect of Bay Leaf Extract Nanoemulsion Preparation ( Syzygium Polyanthum ) on Reducing Myeloperoxidase (Mpo) and Histamine Levels in Kidney Pathology in Wistar Rats with Diabetes Melitus

Abstract

Sudy aimed to evaluate the effect of bay leaf (Syzygium polyanthum) extract nanoemulsion on reducing myeloperoxidase (MPO) levels in Wistar rats with diabetes mellitus. The rats were divided into control and treatment groups, where the treatment group received bay leaf extract nanoemulsion. The results showed that treatment with nanoemulsion significantly reduced MPO levels compared to the control group. Administration of bay leaf extract nanoemulsion Bay leaves ( Syzygium polyanthum) at a concentration of 5% were effective in improving kidney function in Wistar white rats ( Rattus norvegicus ) with diabetes mellitus. This improvement was evident through MPO levels and the histopathological structure of the kidneys, which improved and resembled the control group . The results of histopathological observations of kidney tissue in treatment group 3 were as follows: nanoemulsion extract Bay leaves ( Syzygium Polyanthum) with a concentration of 5% experienced the most significant improvement and were closer to the control group compared to the other groups. Nanoemulsion extract Bay leaves ( Syzygium Polyanthum) contain secondary metabolites in the form of saponins, tannins, flavonoids, and triterpenoids which help repair liver cells that experience fatty liver and necrosis due to diabetes mellitus. Furthermore, histopathological examination of the kidneys showed improvements in kidney tissue, indicating the potential of bay leaf extract in reducing oxidative stress and inflammation. This study concluded that bay leaf extract nanoemulsion preparation could be an effective therapy for managing kidney complications in diabetes mellitus.