Effectiveness of Ginger (Zingiber Officinale) Extract Nanoemulsion Preparation on Blood Glucose Levels, Lipid Profiles, Hba1c and Liver Histopathology in Male Rats Induced by Streptozotocin

Abstract

Study This aim For evaluate effectiveness stock nanoemulsi extract ginger ( Zingiber officinale ) against level glucose blood , lipid profile , and HbA1c in mouse induced male​ streptozotocin , as well as For analyze description histopathology heart . Results study show that stock nanoemulsi extract ginger in a way significant lower level glucose blood , repair lipid profile , and lower level glucose blood , lipid profile , and HbA1c were compared with group control. Administration of ginger extract nanoemulsion ( zingiber officinale ) at a dose of 200 mg/kgBW had an effect on reducing HbA1c levels, indicating an effect on long-term glycemic control. The results of the ANOVA test showed a significant difference between groups (p < 0.05) . Histopathology of ginger extract nanoemulsion ( zingiber officinale ) at a dose of 200 mg/kgBW showed a microscopic picture of the liver of mice in treatment group 3 (P3). It looked normal, no inflammation was seen, the cells began to improve, no looks necrosis and fatty. And scoring For this picture is 1 that is normal. Conclusion from study This is that stock nanoemulsi extract ginger effective in control level glucose blood And lipid profile as well own potential as therapy addition for diabetes mellitus , with effect positive on health heart.