Activity Test of Nano Emulsion Preparation of Star Anise (Illicium Verum) Extract on Reducing Urea and Renal Creatinine Levels in Male Rats Induced by Alloxan

Abstract

Diabetes mellitus is a disease that knows no boundaries, this disease appears when the body cannot control glucose levels. This study aims to test and analyze the effectiveness of the nanoemulsion preparation of star anise (Illicium verum) extract on reducing urea, creatinine, and kidney histopathology in male Wistar rats (Rattus norvegicus) induced by alloxan. The sample of rats used was 24 in 4 groups (positive and negative controls, treatments 1 and 2) where the extract preparation in the treatment was a nanoemulsion of star anise (Illicium verum) extract with a concentration of 10% and 20%. The results of this observation indicate that administration of star anise (Illicium verum) extract with a concentration of 20% can improve the histological structure of the kidneys in male Wistar rats (Rattus norvegicus) with diabetes.