Gc-Ms Instrument Analysis Test Of Nano Emulsion Preparation Of Turmeric Rhizom Extract (Curcuma Domestica Val.) On The Reduction Of Ureum And Creatinine Levels And Histopathological Picture Of The Kidney In Male Rats Induced By Alloxan

Abstract

Study This aim For To determine the potential of nano emulsion preparations of turmeric rhizome extract ( Curcuma domestica val.) and test it on reducing urea and creatinine levels and histopathological features of the kidneys in male rats induced by alloxan. Methods used covering distribution mouse become a number of group treatment , where stock nanoemulsi extract turmeric given orally . Urea levels And creatinine measured before And after treatment , and analysis histopathology done For evaluate change structural on kidney . Results study show that giving nanoemulsi extract turmeric in a way significant lower level urea And creatinine compared to with group control . Turmeric rhizome extract nanoemulsion ( Curcuma Domestica val.) was proven to be effective in reducing blood glucose, urea, and creatinine levels in male Wistar rats (Rattus norvegicus) induced by alloxan . The treatment group given turmeric rhizome extract nanoemulsion ( Curcuma Domestica val.) at a dose of 180 mg/kgbw showed the most optimal results, with a significant decrease in blood sugar, urea, and creatinine levels, approaching the values shown by the control group. In kidney histopathology examination, the group given turmeric rhizome extract nanoemulsion ( Curcuma Domestica val.) at a dose of 180 mg/kgbw also showed minimal tissue damage, characterized by only mild thickening of the glomerular basement membrane, compared to the other groups. Conclusion from study This is that stock nanoemulsi extract rhizome turmeric effective in lower level urea And creatinine , as well as repair condition histopathology kidneys , so that potential as therapy alternative For disturbance function kidney due to diabetes.