Identification of Gc-Ms Nanoemulsion Preparation of Temulawak Extract (Curcuma Zanthorrhiza Roxb) in Improving Kidney Function and Histopathological Features of the Kidneys of Diabetes Mellitus Rats

Abstract

The kidneys are the main organs that can excrete drugs..One of the causes of kidney damage in a person is due to continuously high blood glucose conditions which can lead to diabetes mellitus.This study aims to identify the GC-MS nanoemulsion preparation of temulawak extract (Curcuma Zanthorrhiza Roxb) in improving kidney function and histopathological features of the kidneys of diabetic rats. The sample of rats used was 20 in 5 groups (positive and negative controls, treatments 1, 2 and 3) where the extract preparation in the treatment was in the form ofnanoemulsion of temulawak extractondoses of 50 mg/kgbb, 100 mg/kgbb, 150 mg/kgbb. The results areCompounds such as xanthorrhizol, germacrone, curcumin, and β-caryophyllene are the main candidates in temulawak extract that contribute to its antidiabetic effects. The extract was effective in treating diabetes in mice and improving kidney function at a dose of 150 mg/kg body weight.