THE EFFECT OF GIVING SWEET ORANGE PEEL ETHANOL EXTRACT LOTION (CITRUS SINENSIS) ON WOUND HEALING WISTAR WHITE RAT

Abstract

Wounds are one of the health problems that require proper treatment to speed up the healing process. Natural ingredients, such as sweet orange peel (Citrus sinensis), are known to contain flavonoid compounds, tannins, and antioxidants that have the potential to speed up the wound healing process. This study aims to determine the effect of giving sweet orange peel ethanol extract lotion (Citrus sinensis) on the wound healing process in Wistar white rats, both through macroscopic and microscopic assessments, as well as comparing the effectiveness of various doses (5%, 10%, and 15%). This study uses a true experimental post test only control group design. Wistar white rats were divided into several treatment groups with the administration of EEKNJ lotion concentrations of 5%, 10%, and 15%. Data were analyzed using ANOVA tests. The results showed that the administration of EEKNJ lotion of 5% (sig = 0.005), 10% (sig = 0.000), and 15% (sig = 0.001) had a significant effect in accelerating wound healing. However, ANOVA results on the percentage of wound healing showed a value of sig = 0.901 (> 0.05), which means that there was no significant difference between doses of EEKNJ lotion. Descriptively, the average percentage of highest wound healing was obtained in the EEKNJ group of 10% (38.72%), followed by EEKNJ 5% (35.22%), and the lowest EEKNJ 15% (26.44%). The conclusion of this study is that sweet orange peel ethanol extract lotion has the potential to accelerate wound healing in Wistar white rats, but the dose variations of 5%, 10%, and 15% did not show a significant difference in the wound healing percentage.

Keywords:    Sweet orange peel, Lotion, Wound healing, Wistar white rat